Molecular glues as potential GPCR therapeutics
BL Roth, BE Krumm - Biochemical Pharmacology, 2024 - Elsevier
Abstract “Molecular Glues” are defined as small molecules that can either be endogenous or
synthetic which promote interactions between proteins at their interface. Allosteric …
synthetic which promote interactions between proteins at their interface. Allosteric …
International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors: Structures, functions, activators and blockers
M Behrens - Pharmacological Reviews, 2024 - Elsevier
Bitter perception plays a critical role for the detection of potentially harmful substances in
food items for most vertebrates. The detection of bitter compounds is facilitated by …
food items for most vertebrates. The detection of bitter compounds is facilitated by …
Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist
L Tao, D Wang, Q Yuan, F Zhao, Y Zhang, T Du… - Cell Research, 2024 - nature.com
Dear Editor, Bitter taste perception serves as a vital defense mechanism against potentially
harmful substances in humans. Within the subfamily of bitter taste receptors, known as …
harmful substances in humans. Within the subfamily of bitter taste receptors, known as …
[HTML][HTML] Research on bitter peptides in the field of bioinformatics: a comprehensive review
S Liu, T Shi, J Yu, R Li, H Lin, K Deng - International Journal of Molecular …, 2024 - mdpi.com
Bitter peptides are small molecular peptides produced by the hydrolysis of proteins under
acidic, alkaline, or enzymatic conditions. These peptides can enhance food flavor and offer …
acidic, alkaline, or enzymatic conditions. These peptides can enhance food flavor and offer …
BitterDB: 2024 update on bitter ligands and taste receptors
E Ziaikin, M David, S Uspenskaya… - Nucleic Acids …, 2025 - academic.oup.com
Abstract BitterDB (http://bitterdb. agri. huji. ac. il) was introduced in 2012 as a central
resource for information on bitter-tasting molecules and their receptors, and was updated in …
resource for information on bitter-tasting molecules and their receptors, and was updated in …
A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR
L Peri, D Matzov, DR Huxley, A Rainish, F Fierro… - Nature …, 2024 - nature.com
Bitter taste receptors (TAS2Rs), a subfamily of G-protein coupled receptors (GPCRs)
expressed orally and extraorally, elicit signaling in response to a large set of tastants …
expressed orally and extraorally, elicit signaling in response to a large set of tastants …
Bitter taste receptors as sensors of gut luminal contents
C Sternini, E Rozengurt - Nature Reviews Gastroenterology & …, 2024 - nature.com
Taste is important in the selection of food and is orchestrated by a group of distinct receptors,
the taste G protein-coupled receptors (GPCRs). Taste 1 receptors (Tas1rs in mice and …
the taste G protein-coupled receptors (GPCRs). Taste 1 receptors (Tas1rs in mice and …
Enhancing the quality of dark tea through fermentation with Aspergillus niger: Unveiling aroma and taste characteristics
Amidst the increasing demand for premium dark tea, the utilization of Aspergillus niger-
inoculated fermentation has emerged as a potential solution to address the challenges …
inoculated fermentation has emerged as a potential solution to address the challenges …
Intestinal Taste Receptor Expression and Its Implications for Health: An Integrative Analysis in Female Rats after Chronic Insect Supplementation
H Segú, F Jalševac, M Lores… - Journal of Agricultural …, 2024 - ACS Publications
Taste receptors are found in the gastrointestinal tract, where they are susceptible to dietary
modulation, a key point that is crucial for diet-related responses. Insects are sustainable and …
modulation, a key point that is crucial for diet-related responses. Insects are sustainable and …
Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective
Z Bi, H Li, Y Liang, D Sun, S Liu, W Chen, L Leng… - The Innovation, 2025 - cell.com
Traditional medicines serve not only as an integral part of medical treatments prescribed by
healthcare providers but also as a fundamental reservoir for novel molecular scaffolds …
healthcare providers but also as a fundamental reservoir for novel molecular scaffolds …