The nematode Caenorhabditis elegans stops feeding and moving during a larval transition
stage called lethargus and following exposure to cellular stressors. These behaviors have …

In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

Electrophysiological recordings have enabled identification of physiologically distinct yet
behaviorally similar states of mammalian sleep. In contrast, sleep in nonmammals has …

The nematode C. elegans (worm) is a small invertebrate animal widely used in studies
related to fundamental biological processes, disease modelling, and drug discovery. Due to …

Objectives: Cross-species conservation of sleep-like behaviors predicts the presence of
conserved molecular mechanisms underlying sleep. However, limited experimental …

Neuropeptides have central roles in the regulation of homoeostatic behaviours such as
sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion …

Neurotransmitters signal via G protein coupled receptors (GPCRs) to modulate activity of
neurons and muscles. C. elegans has∼ 150 G protein coupled neuropeptide receptor …

Degeneration is a senescence process that occurs in all living organisms. Although
tremendous efforts have been exerted to alleviate this degenerative tendency, minimal …

Environmental obesogens contributed significantly to the obesity prevalence. Recently,
antibiotics joined the list of environmental obesogens, while the underlying mechanisms …

We demonstrate diffraction-limited and super-resolution imaging through thick layers (tens-
hundreds of microns) of BIO-133, a biocompatible, UV-curable, commercially available …