Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …

Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

The majority of the human genome is not translated into proteins but can be transcribed into
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …

The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and
targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or …

Epigenetic and genetic alterations have long been thought of as two separate mechanisms
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …

Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is
extremely prevalent in pediatric malignant rhabdoid tumors (MRTs) or atypical teratoid …

Mutations within the catalytic domain of the histone methyltransferase EZH2 have been
identified in subsets of patients with non-Hodgkin lymphoma (NHL). These genetic …

The ability to specifically upregulate genes in vivo holds great therapeutic promise. Here we
show that inhibition or degradation of natural antisense transcripts (NATs) by single …