Targeting the RNA m6A modification for cancer immunotherapy
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …
and its dysregulation drives aberrant transcription and translation programs that promote …
Liquid–liquid phase separation in tumor biology
X Tong, R Tang, J Xu, W Wang, Y Zhao, X Yu… - Signal Transduction and …, 2022 - nature.com
Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …
Pan-cancer analysis shows that ALKBH5 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including gliomas
C Wei, B Wang, D Peng, X Zhang, Z Li, L Luo… - Frontiers in …, 2022 - frontiersin.org
Background AlkB homolog 5 (ALKBH5) is a N6-methyladenosine (m6A) demethylase
associated with the development, growth, and progression of multiple cancer types …
associated with the development, growth, and progression of multiple cancer types …
N6-methyladenosine reader YTHDF family in biological processes: structures, roles, and mechanisms
L Chen, Y Gao, S Xu, J Yuan, M Wang, T Li… - Frontiers in …, 2023 - frontiersin.org
As the most abundant and conserved internal modification in eukaryote RNAs, N6-
methyladenosine (m6A) is involved in a wide range of physiological and pathological …
methyladenosine (m6A) is involved in a wide range of physiological and pathological …
[HTML][HTML] The emerging importance role of m6A modification in liver disease
S Wang, S Gao, W Ye, Y Li, J Luan, X Lv - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) modification, as one of the most common types of inner
RNA modification in eukaryotes, plays a multifunctional role in normal and abnormal …
RNA modification in eukaryotes, plays a multifunctional role in normal and abnormal …
RNA-binding proteins in cancer drug discovery
Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
RNA m6A methylation in cancer
Z Wang, J Zhou, H Zhang, L Ge, J Li… - Molecular …, 2023 - Wiley Online Library
N 6‐methyladenosine (m6A) is one of the most abundant internal modifications in eukaryotic
messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic …
messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic …
Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers
D Peng, C Wei, X Zhang, S Li, H Liang, X Zheng… - Cancer Cell …, 2021 - Springer
Background The function of collagen triple helix repeat containing 1 (CTHRC1) as an
oncogene has been reported in a growing number of publications. Bioinformatics methods …
oncogene has been reported in a growing number of publications. Bioinformatics methods …
RNA binding proteins in senescence: a potential common linker for age-related diseases?
Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …
Cationic Lipids‐Mediated Dual‐Targeting of Both Dendritic Cells and Tumor Cells for Potent Cancer Immunotherapy
Impaired antigen presentation either in dendritic cells (DCs) or tumor cells impedes the
triggering of antitumor immunity or tumor cell killing, resulting in failures of multiple types of …
triggering of antitumor immunity or tumor cell killing, resulting in failures of multiple types of …