[HTML][HTML] The bidirectional relationship of depression and inflammation: double trouble

E Beurel, M Toups, CB Nemeroff - Neuron, 2020 - cell.com
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

[HTML][HTML] Sex hormone fluctuation and increased female risk for depression and anxiety disorders: from clinical evidence to molecular mechanisms

M Kundakovic, D Rocks - Frontiers in neuroendocrinology, 2022 - Elsevier
Women are at twice the risk for anxiety and depression disorders as men are, although the
underlying biological factors and mechanisms are largely unknown. In this review, we …

Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts

ASF Kwong, RM Pearson, MJ Adams… - The British journal of …, 2021 - cambridge.org
BackgroundThe COVID-19 pandemic and mitigation measures are likely to have a marked
effect on mental health. It is important to use longitudinal data to improve inferences. AimsTo …

Could polygenic risk scores be useful in psychiatry?: a review

GK Murray, T Lin, J Austin, JJ McGrath, IB Hickie… - JAMA …, 2021 - jamanetwork.com
Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …

Quantifying deviations of brain structure and function in major depressive disorder across neuroimaging modalities

NR Winter, R Leenings, J Ernsting, K Sarink… - JAMA …, 2022 - jamanetwork.com
Importance Identifying neurobiological differences between patients with major depressive
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for …

Animal models of major depression: drawbacks and challenges

B Planchez, A Surget, C Belzung - Journal of Neural Transmission, 2019 - Springer
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study

O Giannakopoulou, K Lin, X Meng, MH Su… - JAMA …, 2021 - jamanetwork.com
Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …

[HTML][HTML] Role of stress in skin diseases: a neuroendocrine-immune interaction view

H Zhang, M Wang, X Zhao, Y Wang, X Chen… - Brain, behavior, and …, 2024 - Elsevier
Psychological stress is a crucial factor in the development of many skin diseases, and the
stigma caused by skin disorders may further increase the psychological burden, forming a …

Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

Y Milaneschi, N Kappelmann, Z Ye, F Lamers… - Molecular …, 2021 - nature.com
We examined whether inflammation is uniformly associated with all depressive and anxiety
symptoms, and whether these associations are potentially causal. Data was from 147,478 …

The genetic architecture of the human cerebral cortex

KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …