Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity
The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
The roles of optogenetics and technology in neurobiology: a review
Optogenetic is a technique that combines optics and genetics to control specific neurons.
This technique usually uses adenoviruses that encode photosensitive protein. The …
This technique usually uses adenoviruses that encode photosensitive protein. The …
Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis
Increased intraocular pressure (IOP) represents a major risk factor for glaucoma, a prevalent
eye disease characterized by death of retinal ganglion cells; lowering IOP is the only proven …
eye disease characterized by death of retinal ganglion cells; lowering IOP is the only proven …
Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness
worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 …
worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 …
The genetic basis for adult onset glaucoma: recent advances and future directions
Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
Molecular genetics of glaucoma: Subtype and ethnicity considerations
Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …
differential presentation as well as ethnic and geographic disparities. The multifactorial …
Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma
MD Drewry, P Challa, JG Kuchtey… - Human molecular …, 2018 - academic.oup.com
Both exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) have been
linked to decreased conventional outflow of aqueous humor (AH). To better understand the …
linked to decreased conventional outflow of aqueous humor (AH). To better understand the …
Pseudoexfoliation syndrome and glaucoma: from genes to disease mechanisms
PEX-associated genes are beginning to reveal relevant biological pathways and processes
involved in disease development. To understand the functional consequences and …
involved in disease development. To understand the functional consequences and …
Clinical implications of recent advances in primary open-angle glaucoma genetics
Over the last decade, genetic studies, including genome-wide association studies (GWAS),
have accelerated the discovery of genes and genomic regions contributing to primary open …
have accelerated the discovery of genes and genomic regions contributing to primary open …
Genome-wide meta-analysis identifies three novel susceptibility loci and reveals ethnic heterogeneity of genetic susceptibility for IgA nephropathy
M Li, L Wang, DC Shi, JN Foo, Z Zhong… - Journal of the …, 2020 - journals.lww.com
Background Eighteen known susceptibility loci for IgAN account for only a small proportion
of IgAN risk. Methods Genome-wide meta-analysis was performed in 2628 patients and …
of IgAN risk. Methods Genome-wide meta-analysis was performed in 2628 patients and …