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Genetic dissection of complex traits
ES Lander, NJ Schork - Focus, 2006 - psychiatryonline.org
Medical genetics was revolutionized during the 1980s by the application of genetic map**
to locate the genes responsible for simple Mendelian diseases. Most diseases and traits …
to locate the genes responsible for simple Mendelian diseases. Most diseases and traits …
QTL analysis in plants; where are we now?
MJ Kearsey, AGL Farquhar - Heredity, 1998 - nature.com
We have briefly reviewed the methods currently available for QTL analysis in segregating
populations and summarized some of the conclusions arising from such analyses in plant …
populations and summarized some of the conclusions arising from such analyses in plant …
Merlin—rapid analysis of dense genetic maps using sparse gene flow trees
Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP)
maps will produce data sets that exceed the limitations of current computational tools. Here …
maps will produce data sets that exceed the limitations of current computational tools. Here …
Map** quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing.
M Georges, D Nielsen, M Mackinnon, A Mishra… - Genetics, 1995 - academic.oup.com
We have exploited" progeny testing" to map quantitative trait loci (QTL) underlying the
genetic variation of milk production in a selected dairy cattle population. A total of 1,518 …
genetic variation of milk production in a selected dairy cattle population. A total of 1,518 …
Present and future of quantitative trait locus analysis in plant breeding
MJ Asins - Plant breeding, 2002 - Wiley Online Library
The joint analysis of genotype marker segregation and phenotypic values of individuals or
lines enables the detection and location of loci affecting quantitative traits (QTL). The …
lines enables the detection and location of loci affecting quantitative traits (QTL). The …
Markov chain Monte Carlo segregation and linkage analysis for oligogenic models
SC Heath - The American Journal of Human Genetics, 1997 - cell.com
A new method for segregation and linkage analysis, with pedigree data, is described.
Reversible jump Markov chain Monte Carlo methods are used to implement a sampling …
Reversible jump Markov chain Monte Carlo methods are used to implement a sampling …
A gender–dependent genetic predisposition to produce high levels of IL‐6 is detrimental for longevity
Current literature indicates that elevated IL‐6 serum levels are associated with diseases,
disability and mortality in the elderly. In this paper, we studied the IL‐6 promoter genetic …
disability and mortality in the elderly. In this paper, we studied the IL‐6 promoter genetic …
Roads, interrupted dispersal, and genetic diversity in timber rattlesnakes
Anthropogenic habitat modification often creates barriers to animal movement, transforming
formerly contiguous habitat into a patchwork of habitat islands with low connectivity …
formerly contiguous habitat into a patchwork of habitat islands with low connectivity …
The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set–recoding and fuzzy inheritance
JR O'Connell, DE Weeks - Nature genetics, 1995 - nature.com
As genetic marker maps have improved, multipoint linkage analysis has become a crucial
part of all disease map** studies. Paradoxically, multipoint lod scores become …
part of all disease map** studies. Paradoxically, multipoint lod scores become …
Detection and integration of genoty** errors in statistical genetics
Detection of genoty** errors and integration of such errors in statistical analysis are
relatively neglected topics, given their importance in gene map**. A few inopportunely …
relatively neglected topics, given their importance in gene map**. A few inopportunely …