Genetic dissection of complex traits

ES Lander, NJ Schork - Focus, 2006 - psychiatryonline.org
Medical genetics was revolutionized during the 1980s by the application of genetic map**
to locate the genes responsible for simple Mendelian diseases. Most diseases and traits …

QTL analysis in plants; where are we now?

MJ Kearsey, AGL Farquhar - Heredity, 1998 - nature.com
We have briefly reviewed the methods currently available for QTL analysis in segregating
populations and summarized some of the conclusions arising from such analyses in plant …

Merlin—rapid analysis of dense genetic maps using sparse gene flow trees

GR Abecasis, SS Cherny, WO Cookson, LR Cardon - Nature genetics, 2002 - nature.com
Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP)
maps will produce data sets that exceed the limitations of current computational tools. Here …

Map** quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing.

M Georges, D Nielsen, M Mackinnon, A Mishra… - Genetics, 1995 - academic.oup.com
We have exploited" progeny testing" to map quantitative trait loci (QTL) underlying the
genetic variation of milk production in a selected dairy cattle population. A total of 1,518 …

Present and future of quantitative trait locus analysis in plant breeding

MJ Asins - Plant breeding, 2002 - Wiley Online Library
The joint analysis of genotype marker segregation and phenotypic values of individuals or
lines enables the detection and location of loci affecting quantitative traits (QTL). The …

Markov chain Monte Carlo segregation and linkage analysis for oligogenic models

SC Heath - The American Journal of Human Genetics, 1997 - cell.com
A new method for segregation and linkage analysis, with pedigree data, is described.
Reversible jump Markov chain Monte Carlo methods are used to implement a sampling …

A gender–dependent genetic predisposition to produce high levels of IL‐6 is detrimental for longevity

M Bonafè, F Olivieri, L Cavallone… - European journal of …, 2001 - Wiley Online Library
Current literature indicates that elevated IL‐6 serum levels are associated with diseases,
disability and mortality in the elderly. In this paper, we studied the IL‐6 promoter genetic …

Roads, interrupted dispersal, and genetic diversity in timber rattlesnakes

RW Clark, WS Brown, R Stechert… - Conservation …, 2010 - Wiley Online Library
Anthropogenic habitat modification often creates barriers to animal movement, transforming
formerly contiguous habitat into a patchwork of habitat islands with low connectivity …

The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set–recoding and fuzzy inheritance

JR O'Connell, DE Weeks - Nature genetics, 1995 - nature.com
As genetic marker maps have improved, multipoint linkage analysis has become a crucial
part of all disease map** studies. Paradoxically, multipoint lod scores become …

Detection and integration of genoty** errors in statistical genetics

E Sobel, JC Papp, K Lange - The American Journal of Human Genetics, 2002 - cell.com
Detection of genoty** errors and integration of such errors in statistical analysis are
relatively neglected topics, given their importance in gene map**. A few inopportunely …