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Aquaporins: important but elusive drug targets
AS Verkman, MO Anderson… - Nature reviews Drug …, 2014 - nature.com
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …
transport across the plasma membranes of cells in response to osmotic gradients. Data from …
Nitric oxide and redox mechanisms in the immune response
The role of redox molecules, such as NO and ROS, as key mediators of immunity has
recently garnered renewed interest and appreciation. To regulate immune responses, these …
recently garnered renewed interest and appreciation. To regulate immune responses, these …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
[HTML][HTML] Guidelines for the use and interpretation of assays for monitoring autophagy 1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah… - …, 2021 - pmc.ncbi.nlm.nih.gov
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Cancer cell plasticity and MHC-II–mediated immune tolerance promote breast cancer metastasis to lymph nodes
Tumor-draining lymph nodes (TDLNs) are important for tumor antigen–specific T cell
generation and effective anticancer immune responses. However, TDLNs are often the …
generation and effective anticancer immune responses. However, TDLNs are often the …
The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments
W Wan, H Dong, DH Lai, J Yang, K He, X Tang… - Nature …, 2023 - nature.com
Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …
The pathogenicity and virulence of Toxoplasma gondii
SG Sanchez, S Besteiro - Virulence, 2021 - Taylor & Francis
Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …
ranging from birds to humans. While this infection is usually asymptomatic in healthy …
Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites
The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular
parasites of humans and animals with immense socio-economic and health impacts. We …
parasites of humans and animals with immense socio-economic and health impacts. We …
The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp
Apicomplexan parasites have complex life cycles, frequently split between different hosts
and reliant on rapid responses as the parasites react to changing environmental conditions …
and reliant on rapid responses as the parasites react to changing environmental conditions …
An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes
K Kremer, D Kamin, E Rittweger, J Wilkes… - PLoS …, 2013 - journals.plos.org
The basic organisation of the endomembrane system is conserved in all eukaryotes and
comparative genome analyses provides compelling evidence that the endomembrane …
comparative genome analyses provides compelling evidence that the endomembrane …