The effects of aging in the hippocampus and cognitive decline

LEB Bettio, L Rajendran, J Gil-Mohapel - Neuroscience & Biobehavioral …, 2017 - Elsevier
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

[HTML][HTML] Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

S Pugazhenthi, L Qin, PH Reddy - … acta (BBA)-molecular basis of disease, 2017 - Elsevier
Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and
obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most …

Neurological consequences of obesity

PD O'Brien, LM Hinder, BC Callaghan… - The Lancet …, 2017 - thelancet.com
The high prevalence of obesity is associated with an enormous medical, social, and
economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by …

Obesity and neuroinflammation: a pathway to cognitive impairment

AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

Metabolic syndrome as a risk factor for Alzheimer's disease: a focus on insulin resistance

A Ezkurdia, MJ Ramírez, M Solas - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the main type of dementia and is a disease with a profound
socioeconomic burden due to the lack of effective treatment. In addition to genetics and …

Food insecurity as a driver of obesity in humans: The insurance hypothesis

D Nettle, C Andrews, M Bateson - Behavioral and Brain Sciences, 2017 - cambridge.org
Integrative explanations of why obesity is more prevalent in some sectors of the human
population than others are lacking. Here, we outline and evaluate one candidate …

Examining the relationship between obesity and cognitive function: a systematic literature review

C Prickett, L Brennan, R Stolwyk - Obesity research & clinical practice, 2015 - Elsevier
The increasing prevalence of both obesity and dementia is a significant public health
concern, especially as recent research demonstrates a significant relationship between …

Central obesity and increased risk of dementia more than three decades later

RA Whitmer, DR Gustafson, E Barrett-Connor… - Neurology, 2008 - AAN Enterprises
Background: Numerous reports show that a centralized distribution of adiposity is a more
dangerous risk factor for cardiovascular disease and diabetes than total body obesity. No …

Factors associated with brain ageing-a systematic review

J Wrigglesworth, P Ward, IH Harding, D Nilaweera… - BMC neurology, 2021 - Springer
Background Brain age is a biomarker that predicts chronological age using neuroimaging
features. Deviations of this predicted age from chronological age is considered a sign of age …

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

M Maalouf, JM Rho, MP Mattson - Brain research reviews, 2009 - Elsevier
Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …