Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

The discovery of cisplatin's antitumor activity in 1969 prompted the search for novel metal-
containing complexes as potential anticancer drugs. Among these novel complexes, metal N …

Platinum complexes are widely used anticancer drugs. New generations of metal
chemotherapeutics offer the prospect of combating platinum resistance and expanding the …

Cells require tight regulation of the intracellular redox balance and consequently of reactive
oxygen species for proper redox signaling and maintenance of metal (eg, of iron and …

A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

Metal complexes have shown interesting preclinical and clinical results as antitumor drugs
and platinum compounds are well established in current cancer chemotherapy. However …

The thioredoxin system plays a key role in regulating the overall intracellular redox balance.
It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine …

Gold compounds are a class of metallodrugs with great potential for cancer treatment.
During the last two decades, a large variety of gold (I) and gold (III) compounds are reported …

From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …