BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …

Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta …

Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result
from complex interplay between genetic and environmental factors. It is well-established that …

Most transcriptome-wide association studies (TWASs) so far focus on European ancestry
and lack diversity. To overcome this limitation, we aggregated genome-wide association …

Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

Substance use disorders (SUDs) are prevalent and result in an array of negative
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …

Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …

Common genetic variants explain less variation in complex phenotypes than inferred from
family-based studies, and there is a debate on the source of this 'missing heritability'. We …