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Carbon metabolism of intracellular bacterial pathogens and possible links to virulence
New technologies such as high-throughput methods and 13C-isotopologue-profiling
analysis are beginning to provide us with insight into the in vivo metabolism of …
analysis are beginning to provide us with insight into the in vivo metabolism of …
Lipoic acid metabolism in microbial pathogens
MD Spalding, ST Prigge - Microbiology and Molecular Biology …, 2010 - journals.asm.org
SUMMARY Lipoic acid [(R)-5-(1, 2-dithiolan-3-yl) pentanoic acid] is an enzyme cofactor
required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly …
required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly …
Fatty acids regulate stress resistance and virulence factor production for Listeria monocytogenes
Fatty acids (FAs) are the major structural component of cellular membranes, which provide a
physical and chemical barrier that insulates intracellular reactions from environmental …
physical and chemical barrier that insulates intracellular reactions from environmental …
Metabolism of the Gram‐Positive Bacterial Pathogen Listeria monocytogenes
The bacterial pathogen Listeria monocytogenes is well adapted to life in the soil and on
vegetation as a saprophyte (ie, extracellular environments) and to life in the cytosol of …
vegetation as a saprophyte (ie, extracellular environments) and to life in the cytosol of …
Optimizing the Balance Between Host and Environmental Survival Skills: Lessons Learned from Listeria monocytogenes
B Xayarath, NE Freitag - Future microbiology, 2012 - Taylor & Francis
Environmental pathogens–organisms that survive in the outside environment but maintain
the capacity to cause disease in mammals–navigate the challenges of life in habitats that …
the capacity to cause disease in mammals–navigate the challenges of life in habitats that …
Listeria monocytogenes CtaP is a multifunctional cysteine transport‐associated protein required for bacterial pathogenesis
B Xayarath, H Marquis, GC Port… - Molecular …, 2009 - Wiley Online Library
The bacterial pathogen Listeria monocytogenes survives under a myriad of conditions in the
outside environment and within the human host where infections can result in severe …
outside environment and within the human host where infections can result in severe …
A chemical proteomic strategy reveals inhibitors of lipoate salvage in bacteria and parasites
JN Dienemann, SY Chen… - Angewandte Chemie …, 2023 - Wiley Online Library
The development of novel anti‐infectives requires unprecedented strategies targeting
pathways which are solely present in pathogens but absent in humans. Following this …
pathways which are solely present in pathogens but absent in humans. Following this …
Staphylococcus aureus SufT: an essential iron‐sulphur cluster assembly factor in cells experiencing a high‐demand for lipoic acid
AA Mashruwala, CA Roberts, S Bhatt… - Molecular …, 2016 - Wiley Online Library
Staphylococcus aureus SufT is composed solely of the domain of unknown function 59
(DUF59) and has a role in the maturation of iron‐sulphur (Fe‐S) proteins. We report that …
(DUF59) and has a role in the maturation of iron‐sulphur (Fe‐S) proteins. We report that …
Branched-Chain Fatty Acids Promote Listeria monocytogenes Intracellular Infection and Virulence
Anteiso-branched-chain fatty acids (BCFA) represent the dominant group of membrane fatty
acids and have been established as crucial determinants in resistance against …
acids and have been established as crucial determinants in resistance against …
Listeria monocytogenes TcyKLMN cystine/cysteine transporter facilitates glutathione synthesis and virulence gene expression
M Brenner, S Friedman, A Haber, N Livnat-Levanon… - Mbio, 2022 - journals.asm.org
Listeria monocytogenes is a saprophyte and a human intracellular pathogen. Upon invasion
into mammalian cells, it senses multiple metabolic and environmental signals that …
into mammalian cells, it senses multiple metabolic and environmental signals that …