Carbon metabolism of intracellular bacterial pathogens and possible links to virulence

W Eisenreich, T Dandekar, J Heesemann… - Nature Reviews …, 2010 - nature.com
New technologies such as high-throughput methods and 13C-isotopologue-profiling
analysis are beginning to provide us with insight into the in vivo metabolism of …

Lipoic acid metabolism in microbial pathogens

MD Spalding, ST Prigge - Microbiology and Molecular Biology …, 2010 - journals.asm.org
SUMMARY Lipoic acid [(R)-5-(1, 2-dithiolan-3-yl) pentanoic acid] is an enzyme cofactor
required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly …

Fatty acids regulate stress resistance and virulence factor production for Listeria monocytogenes

Y Sun, BJ Wilkinson, TJ Standiford… - Journal of …, 2012 - journals.asm.org
Fatty acids (FAs) are the major structural component of cellular membranes, which provide a
physical and chemical barrier that insulates intracellular reactions from environmental …

Metabolism of the Gram‐Positive Bacterial Pathogen Listeria monocytogenes

JD Sauer, AA Herskovits… - Gram‐Positive …, 2019 - Wiley Online Library
The bacterial pathogen Listeria monocytogenes is well adapted to life in the soil and on
vegetation as a saprophyte (ie, extracellular environments) and to life in the cytosol of …

Optimizing the Balance Between Host and Environmental Survival Skills: Lessons Learned from Listeria monocytogenes

B Xayarath, NE Freitag - Future microbiology, 2012 - Taylor & Francis
Environmental pathogens–organisms that survive in the outside environment but maintain
the capacity to cause disease in mammals–navigate the challenges of life in habitats that …

Listeria monocytogenes CtaP is a multifunctional cysteine transport‐associated protein required for bacterial pathogenesis

B Xayarath, H Marquis, GC Port… - Molecular …, 2009 - Wiley Online Library
The bacterial pathogen Listeria monocytogenes survives under a myriad of conditions in the
outside environment and within the human host where infections can result in severe …

A chemical proteomic strategy reveals inhibitors of lipoate salvage in bacteria and parasites

JN Dienemann, SY Chen… - Angewandte Chemie …, 2023 - Wiley Online Library
The development of novel anti‐infectives requires unprecedented strategies targeting
pathways which are solely present in pathogens but absent in humans. Following this …

Staphylococcus aureus SufT: an essential iron‐sulphur cluster assembly factor in cells experiencing a high‐demand for lipoic acid

AA Mashruwala, CA Roberts, S Bhatt… - Molecular …, 2016 - Wiley Online Library
Staphylococcus aureus SufT is composed solely of the domain of unknown function 59
(DUF59) and has a role in the maturation of iron‐sulphur (Fe‐S) proteins. We report that …

Branched-Chain Fatty Acids Promote Listeria monocytogenes Intracellular Infection and Virulence

Y Sun, MXD O'Riordan - Infection and immunity, 2010 - journals.asm.org
Anteiso-branched-chain fatty acids (BCFA) represent the dominant group of membrane fatty
acids and have been established as crucial determinants in resistance against …

Listeria monocytogenes TcyKLMN cystine/cysteine transporter facilitates glutathione synthesis and virulence gene expression

M Brenner, S Friedman, A Haber, N Livnat-Levanon… - Mbio, 2022 - journals.asm.org
Listeria monocytogenes is a saprophyte and a human intracellular pathogen. Upon invasion
into mammalian cells, it senses multiple metabolic and environmental signals that …