Anxiety is the most common mental health problem worldwide. Epidemiological studies
show that sleep disturbances, particularly insomnia, affect∼ 50% of individuals with anxiety …

For hundreds of years, mankind has been influencing its sleep and waking state through the
adenosinergic system. For~ 100 years now, systematic research has been performed, first …

Currently, all treatments for schizophrenia (SCZ) function primarily by blocking D 2-type
dopamine receptors. Given the limitations of these medications, substantial efforts have …

The etiology of psychiatric disorders remains largely unknown. The exploration of the
neurobiological mechanisms of mental illness helps improve diagnostic efficacy and …

Abstract Study Objectives Females demonstrate heightened central sensitization (CS), a risk
factor for chronic pain characterized by enhanced responsivity of central nervous system …

Translational biomarkers, such as prepulse inhibition (PPI) of the acoustic startle response,
are playing an increasingly important role in the development of antipsychotic drugs for …

Sleep quality and architecture as well as sleep's homeostatic and circadian controls change
with healthy aging. Changes include reductions in slow-wave sleep's (SWS) percent and …

An intricate interplay between circadian and sleep–wake homeostatic processes regulate
cognitive performance on specific tasks, and individual differences in circadian preference …

Adenosine and functional A1 adenosine receptor (A1AR) availability are supposed to
mediate sleep–wake regulation and cognitive performance. We hypothesized that cerebral …

Background Insomnia is a common symptom of Major Depressive Disorder (MDD) and
genome-wide association studies pointed to their strong genetic association. Although the …