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Recent advances on cell culture platforms for in vitro drug screening and cell therapies: from conventional to microfluidic strategies
The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical
research based on biologically accurate screening approaches. Since establishing the 2D in …
research based on biologically accurate screening approaches. Since establishing the 2D in …
Three-dimensional cell culture: A powerful tool in tumor research and drug discovery
D Lv, Z Hu, L Lu, H Lu, X Xu - Oncology letters, 2017 - spandidos-publications.com
In previous years, three-dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
BRCA1/2 mutant tumor cells display an elevated mutation burden, the etiology of which
remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous …
remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous …
The extracellular matrix modulates the hallmarks of cancer
The extracellular matrix regulates tissue development and homeostasis, and its
dysregulation contributes to neoplastic progression. The extracellular matrix serves not only …
dysregulation contributes to neoplastic progression. The extracellular matrix serves not only …
Extrusion bioprinting of soft materials: An emerging technique for biological model fabrication
Bioprinting has attracted increasing attention in the tissue engineering field and has been
touted to potentially become the leading technology to fabricate, and regenerate, tissues …
touted to potentially become the leading technology to fabricate, and regenerate, tissues …
[HTML][HTML] Comparison of 2D-and 3D-culture models as drug-testing platforms in breast cancer
It is becoming recognized that screening of oncology drugs on a platform using two-
dimensionally (2D)-cultured cell lines is unable to precisely select clinically active drugs; …
dimensionally (2D)-cultured cell lines is unable to precisely select clinically active drugs; …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
Modeling tumor phenotypes in vitro with three-dimensional bioprinting
The tumor microenvironment plays a critical role in tumor growth, progression, and
therapeutic resistance, but interrogating the role of specific tumor-stromal interactions on …
therapeutic resistance, but interrogating the role of specific tumor-stromal interactions on …
Air− liquid interface cultures of the healthy and diseased human respiratory tract: promises, challenges, and future directions
Air− liquid interface (ALI) culture models currently represent a valid instrument to recreate
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
The role of ultrasound-driven microbubble dynamics in drug delivery: From microbubble fundamentals to clinical translation
In the last couple of decades, ultrasound-driven microbubbles have proven excellent
candidates for local drug delivery applications. Besides being useful drug carriers …
candidates for local drug delivery applications. Besides being useful drug carriers …