Multidrug resistance in Escherichia coli has become a worrying issue that is increasingly
observed in human but also in veterinary medicine worldwide. E. coli is intrinsically …

During the past 85 years of antibiotic use, we have learned a great deal about how these
'miracle'drugs work. We know the molecular structures and interactions of these drugs and …

Bacteria carry extrachromosomal, self-replicating genetic elements called plasmids. A
plasmid is defined as a doublestranded, circular DNA molecule capable of autonomous …

Aminoglycoside antibiotics were among the first antibiotics discovered and used clinically.
Although they have never completely fallen out of favor, their importance has waned due to …

Antibiotic resistance is a major global public health concern. Acinetobacter baumannii is a
nosocomial pathogen that has emerged as a global threat because of its high levels of …

Antibiotic resistance (AR) and multidrug resistance (MDR) have been confirmed for all major
foodborne pathogens: Campylobacter spp., Salmonella spp., Escherichia coli and Listeria …

To create a drug, nature's blueprints often have to be improved through semisynthesis or
total synthesis (chemical postevolution). Selected contributions from industrial and academic …

Methylation of 16S ribosomal RNA (rRNA) has recently emerged as a new mechanism of
resistance against aminoglycosides among gram-negative pathogens belonging to the …

SUMMARY “Common regions”(CRs), such as Orf513, are being increasingly linked to mega-
antibiotic-resistant regions. While their overall nucleotide sequences show little identity to …

Exogenously acquired 16S rRNA methyltransferase (16S-RMTase) genes responsible for a
very high level of resistance against various aminoglycosides have been widely distributed …