Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …

Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

Despite a conserved role for histones as general DNA packaging agents, it is now clear that
another key function of these proteins is to confer variations in chromatin structure to ensure …

We sequenced the MSY (male-specific region of the Y chromosome) of the C57BL/6J strain
of the laboratory mouse Mus musculus. In contrast to theories that Y chromosomes are …

Spermiogenesis is a complex cellular differentiation process that the germ cells undergo a
distinct morphological change, and the protamines replace the core histones to facilitate …

Eukaryotic gene regulation involves a balance between packaging of the genome into
nucleosomes and enabling access to regulatory proteins and RNA polymerase …

In eukaryotes, DNA is organized together with histones and non-histone proteins into a
highly complex nucleoprotein structure called chromatin, with the nucleosome as its …

Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin
structure. The known number of such variants has greatly increased in recent years, but the …