Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology, target identification, and in the in vivo evaluation of novel …

The assessment of pain, distress and suffering, as well as evaluation of the efficacy of stress-
reduction strategies, is crucial in animal experimentation but can be challenging in …

The measurement of pain in animals is surprisingly complex, and remains a critical issue in
veterinary care and biomedical research. Based on the known utility of pain measurement …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

We review studies claiming that fish feel pain and find deficiencies in the methods used for
pain identification, particularly for distinguishing unconscious detection of injurious stimuli …

Pain inhibition by additional somatosensory input is the rationale for the widespread use of
Transcutaneous Electrical Nerve Stimulation (TENS) to relieve pain. Two main types of …

Tricyclic antidepressants, together with anticonvulsants, are considered to be first-line drugs
for the treatment of neuropathic pain. Antidepressants are analgesic in patients with chronic …

Inflammatory pain impacts adversely on the quality of life of patients, often resulting in motor
disabilities. Therefore, we studied the effect of peripheral inflammation induced by …

Neuropathic pain remains an area of considerable unmet clinical need. Research based on
preclinical animal models has failed to deliver truly novel treatment options, questioning the …