New developments in neutrophil biology and periodontitis

G Hajishengallis - Periodontology 2000, 2020 - Wiley Online Library
Neutrophils have been historically associated with antimicrobial functions in acute infections
but are now appreciated as functionally versatile cells with critical roles in chronic …

The periodontal war: microbes and immunity

JL Ebersole, D Dawson III, P Emecen‐Huja… - Periodontology …, 2017 - Wiley Online Library
Maintenance of periodontal health or transition to a periodontal lesion reflects the
continuous and ongoing battle between the vast microbial ecology in the oral cavity and the …

Deciphering coral disease dynamics: integrating host, microbiome, and the changing environment

R Vega Thurber, LD Mydlarz, M Brandt… - Frontiers in Ecology …, 2020 - frontiersin.org
Diseases of tropical reef organisms is an intensive area of study, but despite significant
advances in methodology and the global knowledge base, identifying the proximate causes …

Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis

C Slocum, C Kramer, CA Genco - Journal of internal medicine, 2016 - Wiley Online Library
Cardiovascular disease is an inflammatory disorder characterized by the progressive
formation of plaque in coronary arteries, termed atherosclerosis. It is a multifactorial disease …

The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases

CJ Carter, J France, SJ Crean… - Frontiers in aging …, 2017 - frontiersin.org
Periodontal disease is of established etiology in which polymicrobial synergistic ecology has
become dysbiotic under the influence of Porphyromonas gingivalis. Following breakdown of …

Oral microbiome mediated inflammation, a potential inductor of vascular diseases: a comprehensive review

DF Gualtero, GI Lafaurie, DM Buitrago… - Frontiers in …, 2023 - frontiersin.org
The dysbiosis of the oral microbiome and vascular translocation of the periodontopathic
microorganism to peripheral blood can cause local and systemic extra-oral inflammation …

Complement and dysbiosis in periodontal disease

G Hajishengallis, JD Lambris - Immunobiology, 2012 - Elsevier
Signaling crosstalk between complement and Toll-like receptors (TLRs) normally serves to
coordinate host immunity. However, the periodontal bacterium Porphyromonas gingivalis …

The complex molecular picture of gut and oral microbiota–brain-depression system: what we know and what we need to know

C Scassellati, M Marizzoni, N Cattane… - Frontiers in …, 2021 - frontiersin.org
Major depressive disorder (MDD) is a complex mental disorder where the neurochemical,
neuroendocrine, immune, and metabolic systems are impaired. The microbiota-gut-brain …

Porphyromonas gingivalis initiates a mesenchymal‐like transition through ZEB1 in gingival epithelial cells

MN Sztukowska, A Ojo, S Ahmed… - Cellular …, 2016 - Wiley Online Library
The oral anaerobe Porphyromonas gingivalis is associated with the development of cancers
including oral squamous cell carcinoma (OSCC). Here, we show that infection of gingival …

Biomarkers and bacteria around implants and natural teeth in the same individuals

Ö Gürlek, P Gümüş, CJ Nile, DF Lappin… - Journal of …, 2017 - Wiley Online Library
Background: This cross‐sectional study assesses cytokine levels in peri‐implant crevicular
fluid (PICF)/gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque …