Reverse-genetics studies of lncRNAs—what we have learnt and paths forward
Long non-coding RNAs (lncRNAs) represent a major fraction of the transcriptome in
multicellular organisms. Although a handful of well-studied lncRNAs are broadly recognized …
multicellular organisms. Although a handful of well-studied lncRNAs are broadly recognized …
Genotype–Phenotype relationships in the context of transcriptional adaptation and genetic robustness
G Jakutis, DYR Stainier - Annual review of genetics, 2021 - annualreviews.org
Genetic manipulations with a robust and predictable outcome are critical to investigate gene
function, as well as for therapeutic genome engineering. For many years, knockdown …
function, as well as for therapeutic genome engineering. For many years, knockdown …
Blueprint for cancer research: critical gaps and opportunities
LW Elmore, SF Greer, EC Daniels… - CA: A Cancer …, 2021 - Wiley Online Library
We are experiencing a revolution in cancer. Advances in screening, targeted and immune
therapies, big data, computational methodologies, and significant new knowledge of cancer …
therapies, big data, computational methodologies, and significant new knowledge of cancer …
Natural antisense transcripts as versatile regulators of gene expression
Long non-coding RNAs (lncRNAs) are emerging as a major class of gene products that
have central roles in cell and developmental biology. Natural antisense transcripts (NATs) …
have central roles in cell and developmental biology. Natural antisense transcripts (NATs) …
Centromeric and pericentric transcription and transcripts: their intricate relationships, regulation, and functions
J Zhu, Q Guo, M Choi, Z Liang, KWY Yuen - Chromosoma, 2023 - Springer
Centromeres are no longer considered to be silent. Both centromeric and pericentric
transcription have been discovered, and their RNA transcripts have been characterized and …
transcription have been discovered, and their RNA transcripts have been characterized and …
Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans
Methylation of carbon‐5 of cytosines (m5C) is a post‐transcriptional nucleotide modification
of RNA found in all kingdoms of life. While individual m5C‐methyltransferases have been …
of RNA found in all kingdoms of life. While individual m5C‐methyltransferases have been …
LncRNAs in molluscan and mammalian stages of parasitic schistosomes are developmentally-regulated and coordinately expressed with protein-coding genes
Despite the low level expression of some long noncoding RNAs (lncRNAs), the differential
expression of specific lncRNAs plays important roles during the development of many …
expression of specific lncRNAs plays important roles during the development of many …
Functional intricacy and symmetry of long non-coding rnas in parasitic infections
RNAs are a class of molecules and the majority in eukaryotes are arbitrarily termed non-
coding transcripts which are broadly classified as short and long non-coding RNAs …
coding transcripts which are broadly classified as short and long non-coding RNAs …
LncRNA Functional Screening in Organismal Development
Y Li, H Zhai, L Tong, C Wang, Z **e, K Zheng - Non-coding RNA, 2023 - mdpi.com
Controversy continues over the functional prevalence of long non-coding RNAs (lncRNAs)
despite their being widely investigated in all kinds of cells and organisms. In animals …
despite their being widely investigated in all kinds of cells and organisms. In animals …
Post-transcriptional regulation shapes the transcriptome of quiescent budding yeast
AC Greenlaw, KG Alavattam… - Nucleic Acids …, 2024 - academic.oup.com
To facilitate long-term survival, cells must exit the cell cycle and enter quiescence, a
reversible non-replicative state. Budding yeast cells reprogram their gene expression during …
reversible non-replicative state. Budding yeast cells reprogram their gene expression during …