The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …

MetaboLights is a global database for metabolomics studies including the raw experimental
data and the associated metadata. The database is cross-species and cross-technique and …

Toxicogenomics measures molecular features, such as transcripts, proteins, metabolites and
epigenomic modifications, to understand and predict the toxicological effects of …

Metabolomics is a discipline aiming to characterize the presence of metabolites in biological
matrices under specific conditions. In recent years, metabolomics has increasingly been …

While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …

Targeted metabolite assays that measure tens or hundreds of pre-selected metabolites,
typically using liquid chromatography–mass spectrometry, are increasingly being developed …

Use of molecular data in human and ecological health risk assessments of industrial
chemicals and agrochemicals has been anticipated by the scientific community for many …

The development of alternative methods to animal testing has gained great momentum
since Russel and Burch introduced the “3Rs” concept of Reduction, Refinement, and …

Environmental toxicology and ecotoxicology research efforts are employing proteomics with
fish models as New Approach Methodologies, along with in silico, in vitro and other omics …