The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

We review the morphofunctional characteristics of pericytes and report our observations.
After a brief historical background, we consider the following aspects of pericytes: A) Origin …

Summary DNA N 6-methyladenine (6mA) modification is commonly found in microbial
genomes and plays important functions in regulating numerous biological processes in …

Background A longstanding goal in regenerative medicine is to reconstitute functional tissus
or organs after injury or disease. Attention has focused on the identification and relative …

Monocytes and macrophages play a critical role in tissue development, homeostasis, and
injury repair. These innate immune cells participate in guiding vascular remodeling …

The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which
reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro …

It has been one and a half centuries since Enrico Sertoli published the seminal discovery of
the testicular 'nurse cell', not only a key cell in the testis, but indeed one of the most amazing …

The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have
recently demonstrated the presence of about six cycling Lgr5+ stem cells at the bottoms of …

Graphene, a one‐atom‐thick two‐dimensional (2D) layer of sp2‐bonded carbon, has
received worldwide attention owing to its extraordinary physical and chemical properties …