Selective permeation of sodium ions through voltage-dependent sodium channels is
fundamental to the generation of action potentials in excitable cells such as neurons. These …

Voltage-gated ion channels generate electrical signals in species from bacteria to man.
Their voltage-sensing modules are responsible for initiation of action potentials and graded …

Voltage-gated sodium (Na v) channels initiate and propagate action potentials. Here, we
present the cryo-EM structure of EeNa v 1.4, the Na v channel from electric eel, in complex …

We found that caveolin-2 is targeted to the surface of lipid droplets (Fujimoto, T., Kogo, H.,
Ishiguro, K., Tauchi, K., and Nomura, R.(2001) J. Cell Biol. 152, 1079–1085) and …

The energetics of CNS white matter are poorly understood. We derive a signaling energy
budget for the white matter (based on data from the rodent optic nerve and corpus callosum) …

When asked to draw up a list of textbook substituents, hardly anyone would consider to
associate such an “exotic entity” like trifluoromethoxy to the lastingly popular carboxy, acetyl …

The mechanosensitive channel of small conductance (MscS) responds both to stretching of
the cell membrane and to membrane depolarization. The crystal structure at 3.9 angstroms …

Complex multicellular organisms require rapid and accurate transmission of information
among cells and tissues and tight coordination of distant functions. Electrical signals and …

The pore-forming subunits of canonical voltage-gated sodium and calcium channels are
encoded by four repeated domains of six-transmembrane (6TM) segments. We expressed …

Abstract Type I interferons (IFN-I) are important cytokines linking innate and adaptive
immunity. Plasmacytoid dendritic cells make high levels of IFN-I in response to viral infection …