Optical techniques have revolutionized the investigation of cardiac cellular physiology and
advanced our understanding of basic mechanisms of electrical activity, calcium …

Restitution and Spatial Heterogeneities vs Arrhythmias. Introduction: The slope of the action
potential duration (APD) restitution curve has been used to explain wavebreaks during …

Background—Conduction abnormalities serve as a substrate for ventricular fibrillation (VF)
in patients with Brugada syndrome (BS). Signal-averaged electrograms can detect late …

Objectives This study sought to identify subcellular Ca2+ signals within and among cells
comprising the sinoatrial node (SAN) tissue. Background The current paradigm of SAN …

Background—Matrix metalloproteinases (MMPs) contribute to left ventricular remodeling
after myocardial infarction (MI). Specific causative roles of particular MMPs, however, remain …

The heterogeneous distribution of ion channels in ventricular muscle gives rise to spatial
variations in action potential (AP) duration (APD) and contributes to the repolarization …

Transmembrane voltage-sensitive fluorescence measurements are limited by baseline drift
that can obscure changes in resting membrane potential and by motion artifacts that can …

Optical map** studies have suggested that intracellular Ca2+ and T-wave alternans are
linked through underlying alternations in Ca2+ cycling-inducing oscillations in action …

The cardiac myocyte has an intracellular scaffold, the cytoskeleton, which has been
implicated in several cardiac pathologies including hypertrophy and failure. In this review we …

Chronic rapid atrial pacing (RAP) leads to changes that perpetuate atrial fibrillation (AF).
Chronic atrial dilatation due to mitral regurgitation (MR) also increases AF inducibility, but it …