Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

E7 is an accessory protein that is not encoded by all papillomaviruses. The E7 amino
terminus contains two regions of similarity to conserved regions 1 and 2 of the adenovirus …

The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …

High-throughput technologies, offering an unprecedented wealth of quantitative data
underlying the makeup of living systems, are changing biology. Notably, the systematic …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
http://thebiogrid. org) is an open access database that houses genetic and protein …

In the post-genomic era, the elucidation of the relationship between the molecular origins of
diseases and their resulting phenotypes is a crucial task for medical research. Here, we use …

Studying protein interaction networks of all proteins in an organism (“interactomes”) remains
one of the major challenges in modern biomedicine. Such information is crucial to …

Genotypic differences greatly influence susceptibility and resistance to disease.
Understanding genotype–phenotype relationships requires that phenotypes be viewed as …

Viruses elicit cell and organismic stress, and offset homeostasis. They trigger intrinsic, innate
and adaptive immune responses, which limit infection. Viruses restore homeostasis by …

Abstract VirHostNet release 2.0 (http://virhostnet. prabi. fr) is a knowledgebase dedicated to
the network-based exploration of virus–host protein–protein interactions. Since the previous …