Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies
J Zhang, Y Zhang, J Wang, Y **a, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …
The role of autophagy in the heart
S Sciarretta, Y Maejima, D Zablocki… - Annual review of …, 2018 - annualreviews.org
Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are
degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac …
degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac …
Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence
H Tai, Z Wang, H Gong, X Han, J Zhou, X Wang… - Autophagy, 2017 - Taylor & Francis
Macroautophagy/autophagy has profound implications for aging. However, the true features
of autophagy in the progression of aging remain to be clarified. In the present study, we …
of autophagy in the progression of aging remain to be clarified. In the present study, we …
Signaling by the phosphoinositide 3-kinase family in immune cells
K Okkenhaug - Annual review of immunology, 2013 - annualreviews.org
Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
[HTML][HTML] Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives
M Zhang, S Serna-Salas, T Damba… - Mechanisms of ageing …, 2021 - Elsevier
Myofibroblasts play an important role in fibrogenesis. Hepatic stellate cells are the main
precursors of myofibroblasts. Cellular senescence is the terminal cell fate in which …
precursors of myofibroblasts. Cellular senescence is the terminal cell fate in which …
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease
Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's
disease (AD), but the underlying assumption that neurons are the main source of pathogenic …
disease (AD), but the underlying assumption that neurons are the main source of pathogenic …
Paraptosis: a unique cell death mode for targeting cancer
Programmed cell death (PCD) is the universal process that maintains cellular homeostasis
and regulates all living systems' development, health and disease. Out of all, apoptosis is …
and regulates all living systems' development, health and disease. Out of all, apoptosis is …
Autophagy and lipid droplets in the liver
Autophagy is a conserved quality-control pathway that degrades cytoplasmic contents in
lysosomes. Autophagy degrades lipid droplets through a process termed lipophagy …
lysosomes. Autophagy degrades lipid droplets through a process termed lipophagy …
Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: a challenge for neuroprotection
J Puyal, V Ginet, PGH Clarke - Progress in neurobiology, 2013 - Elsevier
There is currently no approved neuroprotective pharmacotherapy for acute conditions such
as stroke and cerebral asphyxia. One of the reasons for this may be the multiplicity of cell …
as stroke and cerebral asphyxia. One of the reasons for this may be the multiplicity of cell …