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Myocardial ischaemia–reperfusion injury and cardioprotection in perspective
G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …
Ischemic heart disease pathophysiology paradigms overview: from plaque activation to microvascular dysfunction
P Severino, A D'Amato, M Pucci, F Infusino… - International journal of …, 2020 - mdpi.com
Ischemic heart disease still represents a large burden on individuals and health care
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …
[HTML][HTML] Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis
Z Wang, M Yao, L Jiang, L Wang, Y Yang… - Biomedicine & …, 2022 - Elsevier
The present study aimed to investigate whether dexmedetomidine (Dex) exerts
cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury …
cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury …
Randomized trial of interleukin-6 receptor inhibition in patients with acute ST-segment elevation myocardial infarction
K Broch, AK Anstensrud, S Woxholt, K Sharma… - Journal of the American …, 2021 - jacc.org
Background Prompt myocardial revascularization with percutaneous coronary intervention
(PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation …
(PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation …
[HTML][HTML] Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway
C Cai, Z Guo, X Chang, Z Li, F Wu, J He, T Cao… - Redox Biology, 2022 - Elsevier
Mitophagy preserves microvascular structure and function during myocardial
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …
[HTML][HTML] Inflammation in myocardial ischemia/reperfusion injury: Underlying mechanisms and therapeutic potential
J Francisco, DP Del Re - Antioxidants, 2023 - mdpi.com
Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …
Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice
Y Song, B Wang, X Zhu, J Hu, J Sun, J Xuan… - Cell Biology and …, 2021 - Springer
The exosome of MSCs derived from human umbilical cord blood (HUCB-MSC) has been
reported to have cardioprotective effects on mouse models of acute myocardial infarction …
reported to have cardioprotective effects on mouse models of acute myocardial infarction …
[HTML][HTML] Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised …
DJ Hausenloy, RK Kharbanda, UK Møller, M Ramlall… - The Lancet, 2019 - thelancet.com
Background Remote ischaemic conditioning with transient ischaemia and reperfusion
applied to the arm has been shown to reduce myocardial infarct size in patients with ST …
applied to the arm has been shown to reduce myocardial infarct size in patients with ST …
Mitochondria in acute myocardial infarction and cardioprotection
Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the
leading causes of death and disability worldwide. As such, new treatments are needed to …
leading causes of death and disability worldwide. As such, new treatments are needed to …
Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Despite prompt epicardial recanalization in patients presenting with ST-segment elevation
myocardial infarction (STEMI), coronary microvascular obstruction and dysfunction (CMVO) …
myocardial infarction (STEMI), coronary microvascular obstruction and dysfunction (CMVO) …