The SLC8 gene family of sodium–calcium exchangers (NCX)–Structure, function, and regulation in health and disease

D Khananshvili - Molecular aspects of medicine, 2013‏ - Elsevier
The SLC8 gene family encoding Na+/Ca2+ exchangers (NCX) belongs to the CaCA
(Ca2+/Cation Antiporter) superfamily. Three mammalian genes (SLC8A1, SLC8A2, and …

On the special role of NCX in astrocytes: Translating Na+-transients into intracellular Ca2+ signals

CR Rose, D Ziemens, A Verkhratsky - Cell Calcium, 2020‏ - Elsevier
As a solute carrier electrogenic transporter, the sodium/calcium exchanger (NCX1-
3/SLC8A1-A3) links the trans-plasmalemmal gradients of sodium and calcium ions (Na+, Ca …

Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences

D Bano, M Ankarcrona - Neuroscience letters, 2018‏ - Elsevier
Over the past several decades, an overwhelming body of research has greatly expanded
our understanding of the mechanisms underlying excitotoxicity in brain ischemia as well as …

[HTML][HTML] Novel insight into the role of A-kinase anchoring proteins (AKAPs) in ischemic stroke and therapeutic potentials

Z He, L **e, J Liu, X Wei, W Zhang, Z Mei - Biomedicine & Pharmacotherapy, 2024‏ - Elsevier
Ischemic stroke, a devastating disease associated with high mortality and disability
worldwide, has emerged as an urgent public health issue. A-kinase anchoring proteins …

Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400

Y Dong, Z Yu, Y Li, B Huang, Q Bai, Y Gao… - The EMBO …, 2024‏ - embopress.org
Sodium-calcium exchanger proteins influence calcium homeostasis in many cell types and
participate in a wide range of physiological and pathological processes. Here, we elucidate …

Ionic regulation of cell volume changes and cell death after ischemic stroke

M Song, SP Yu - Translational stroke research, 2014‏ - Springer
Stroke is a leading cause of human death and disability in the USA and around the world.
Shortly after the cerebral ischemia, cell swelling is the earliest morphological change in …

The cardiac Na+-Ca2+ exchanger: from structure to function

M Ottolia, S John, A Hazan… - Comprehensive …, 2021‏ - pmc.ncbi.nlm.nih.gov
Ca2+ homeostasis is essential for cell function and survival. As such, the cytosolic Ca2+
concentration is tightly controlled by a wide number of specialized Ca2+ handling proteins …

Sodium transporters in human health and disease

KB Gagnon, E Delpire - Frontiers in Physiology, 2021‏ - frontiersin.org
Sodium (Na+) electrochemical gradients established by Na+/K+ ATPase activity drives the
transport of ions, minerals, and sugars in both excitable and non-excitable cells. Na+ …

[HTML][HTML] The dopamine system: insights between kidney and brain

A de Donato, V Buonincontri, G Borriello… - Kidney and Blood …, 2022‏ - karger.com
Background: Chronic kidney disease (CKD) is one of the most common diseases in adult
age, and it is typical of older adults. Recent data suggest that almost half of the elders have …