Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …

DNA interacting enzymes recognize their target sequences embedded in variable flanking
sequence context. The influence of flanking sequences on enzymatic activities of DNA …

Abstract DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and
maintaining DNA methylation patterns in vertebrates. Here we structurally and biochemically …

Background DNA methylation is an epigenetic mark associated with the repression of gene
promoters. Its pattern in the genome is disrupted with age and these changes can be used to …

DNA methylation at the fifth position of cytosine (5mC) is one of the most studied epigenetic
mechanisms essential for the control of gene expression and for many other biological …

The stability of the human telomere G-quadruplex (G4) is directly linked to cancer disease.
The human telomere is mostly associated with the flanking nucleobases, which can affect …

In mammalian embryos, DNA methylation is initialized to maximum levels in the epiblast by
the de novo DNA methyltransferases DNMT3A and DNMT3B before gastrulation diversifies …

Mammalian genomes are methylated on carbon-5 of many cytosines, mostly in CpG
dinucleotides. Methylation patterns are maintained during mitosis via DNMT1, and …

Hydroquinone (HQ), one of the main active metabolites of benzene, can induce the
abnormal expression of long non-coding RNA (lncRNA). Studies have shown that lncRNA …

DNA methylation is a key epigenetic modification to regulate gene expression in mammalian
cells. Abnormal DNA methylation in gene promoters is common across human cancer types …