Schlafen (SLFN) genes belong to a vertebrate gene family encoding proteins with high
sequence homology. However, each SLFN is functionally divergent and differentially …

DNA-damaging agents exploit increased genomic instability, a hallmark of cancer. Recently,
inhibitors targeting the DNA damage response (DDR) pathways, such as PARP inhibitors …

The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the
protracted timing of human brain development, extending over months to years for reaching …

Nucleic acids are major structures detected by the innate immune system. Although
intracellular single-stranded DNA (ssDNA) accumulates during pathogen infection or …

Abstract Schlafen 11 (SLFN11) is an interferon-inducible antiviral restriction factor with tRNA
endoribonuclease and DNA binding functions. It is recruited to stalled replication forks in …

Schlafen-11 (SLFN11) inactivation in∼ 50% of cancer cells confers broad chemoresistance.
To identify therapeutic targets and underlying molecular mechanisms for overcoming …

Abstract Background Schlafen 11 (SLFN11) has been linked with response to DNA-
damaging agents (DDA) and PARP inhibitors. An in-depth understanding of several aspects …

The Schlafen family belongs to the interferon-stimulated genes and its members are
involved in cell cycle regulation, T cell quiescence, inhibition of viral replication, DNA-repair …

Abstract Human Schlafen 11 (SLFN11) is sensitizing cells to DNA damaging agents by
irreversibly blocking stalled replication forks, making it a potential predictive biomarker in …

Abstract Schlafen11 (SLFN11) inactivation occurs in approximately 50% of cancer cell lines
and in a large fraction of patient tumor samples, which leads to chemoresistance. Therefore …