Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Abstract The 3, 3′‐pyrrolidinyl‐spirooxindole unit is a privileged heterocyclic motif that
forms the core of a large family of alkaloid natural products with strong bioactivity profiles …

The design and implementation of cascade reactions is a challenging facet of organic
chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic …

The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry,
and it laid the ground for the early days of target-oriented organic synthesis. 1 Since then …

Pyrrole is one of the most important one-ring heterocycles. The ready availability of suitably
substituted and functionalized pyrrole derivatives is essential for the progress of many …

Which compound classes are best suited as probes and tools for chemical biology research
and as inspiration for medicinal chemistry programs? Chemical space is enormously large …

Polyheterocycles are one of the most desired synthetic targets due to their numerous and
valuable applications in various fields. Multicomponent reactions (MCRs) are highly …

Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies
and applications for multicomponent reactions–including key routes for synthesizing …

Isatins are well‐known carbonyl electrophiles which allow a vast number of reactions
initiated by nucleophilic attack on the C3 carbonyl group when used as starting materials …

Abstract The Groebke–Blackburn–Bienaymé reaction (GBBR) is used for the one-pot
synthesis of therapeutically relevant fused imidazoles bridgehead nitrogen heterocyclic …