An association between human papillomavirus (HPV) infection and the development of
cervical cancer was initially reported over 30 years ago, and today there is overwhelming …

In industrialized countries, population wide cytological screening programs using the Pap
test have led to a substantial reduction of the incidence of cervical cancer. Despite this …

The progressive loss of immunological memory during aging correlates with a reduced
proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. Recently, the incidence of oropharyngeal cancer (OPC) has increased markedly …

BACKGROUND The telomerase reverse transcriptase (TERT) promoter mutations C228T
and C250T have been found in many malignancies, including in thyroid carcinomas …

Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and
essential to chromosome stability/integrity. In normal human cells, telomere length erodes …

Introduction 3. What are telomeres? 4. Telomere shortening occurs naturally in human
somatic cells 5. Telomerase adds telomeres to the end of linear chromosomes 6. Telomere …

With between 10% and 15% of human cancers attributable to viral infection, there is great
interest, from both a scientific and clinical viewpoint, as to how these pathogens modulate …

The first experimental data suggesting that neoplasm development in animals might be
influenced by infectious agents were published in the early 1900s. However, conclusive …

Colorectal cancer (CRC) is the third leading cause of cancer death worldwide, which is
consequence of multistep tumorigenesis of several genetic and epigenetic events. Since …