Heterotopic ossification (HO) is defined as the occurrence of extraskeletal bone in soft
tissue. Although this pathological osteogenesis process involves the participation of …

The field of research on pain originating from various bone diseases is expanding rapidly,
with new mechanisms and targets asserting both peripheral and central sites of action. The …

Inflammatory arthritis, primarily including rheumatoid arthritis, osteoarthritis and ankylosing
spondylitis, is a group of chronic inflammatory diseases, whose general feature is joint …

Heterotopic ossification (HO), including hereditary and acquired HO, is the formation of
extraskeletal bone in skeletal muscle and surrounding soft tissues. Acquired HO is often …

Bony fusion caused by pathological new bone formation manifests the clinical feature of
ankylosing spondylitis (AS). However, the underlying mechanism remains elusive. Here we …

This study aimed to investigate whether Forkhead box O3a (FOXO3a) modulates
inflammation and oxidative stress in ankylosing spondylitis (AS). We applied bioinformatics …

Objectives The aim of this study was to identify the role of tenascin-C (TNC) in entheseal
new bone formation and to explore the underlying molecular mechanism. Methods Ligament …

Rheumatic diseases constitute a diversified group of diseases distinguished by arthritis and
often involve other organs. The affected individual has low quality of life, productivity even …

Ankylosing spondylitis (AS) is clinically characterized by bone fusion that is induced by the
pathological formation of extra bone. Unfortunately, the fundamental mechanism and related …

Background Ankylosing Spondylitis (AS) is an inflammatory condition affecting the spine,
which may lead to complications such as osteoporosis (OP). Many observational studies …