Novel insights into double-stranded RNA-mediated immunopathology
Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
ADAR1: from basic mechanisms to inhibitors
J Rehwinkel, P Mehdipour - Trends in Cell Biology, 2024 - cell.com
Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …
The competitive landscape of the dsRNA world
The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …
Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes
Trained immunity describes the capacity of innate immune cells to develop heterologous
memory in response to certain exogenous exposures. This phenomenon mediates, at least …
memory in response to certain exogenous exposures. This phenomenon mediates, at least …
PANoptosis: Mechanisms, biology, and role in disease
X Sun, Y Yang, X Meng, J Li, X Liu… - Immunological …, 2024 - Wiley Online Library
Cell death can be executed through distinct subroutines. PANoptosis is a unique
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer
TL Wong, JJ Loh, S Lu, HHN Yan, HC Siu, R **… - Nature …, 2023 - nature.com
Targetable drivers governing 5-fluorouracil and cisplatin (5FU+ CDDP) resistance remain
elusive due to the paucity of physiologically and therapeutically relevant models. Here, we …
elusive due to the paucity of physiologically and therapeutically relevant models. Here, we …
ADAR1 and its implications in cancer development and treatment
AR Baker, FJ Slack - Trends in Genetics, 2022 - cell.com
The family of adenosine deaminases acting on RNA (ADARs) regulates global gene
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …
Adenosine deaminases acting on RNA (ADARs) and viral infections
C6 deamination of adenosine (A) to inosine (I) in double-stranded RNA (dsRNA) is
catalyzed by a family of enzymes known as ADARs (adenosine deaminases acting on RNA) …
catalyzed by a family of enzymes known as ADARs (adenosine deaminases acting on RNA) …
RNA modifications in cardiovascular health and disease
RNA is not always a faithful copy of DNA. Advances in tools enabling the interrogation of the
exact RNA sequence have permitted revision of how genetic information is transferred. We …
exact RNA sequence have permitted revision of how genetic information is transferred. We …
ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1
(ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS) …
(ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS) …