Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape

JH Lorent, KR Levental, L Ganesan… - Nature chemical …, 2020 - nature.com
A fundamental feature of cellular plasma membranes (PMs) is an asymmetric lipid
distribution between the bilayer leaflets. However, neither the detailed, comprehensive …

Insights into asymmetric liposomes as a potential intervention for drug delivery including pulmonary nanotherapeutics

YN Al Badri, CS Chaw, AA Elkordy - Pharmaceutics, 2023 - mdpi.com
Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that
can encapsulate a broad range of small drug molecules (hydrophilic and hydrophobic …

Seeing the membrane from both sides now: lipid asymmetry and its strange consequences

M Doktorova, I Levental… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Almost all biomembranes are constructed as lipid bilayers and, in almost all of these, the two
opposing monolayers (leaflets) have distinct lipid compositions. This lipid asymmetry arises …

On the mechanism of bilayer separation by extrusion, or why your LUVs are not really unilamellar

HL Scott, A Skinkle, EG Kelley, MN Waxham… - Biophysical journal, 2019 - cell.com
Extrusion through porous filters is a widely used method for preparing biomimetic model
membranes. Of primary importance in this approach is the efficient production of single …

Scaling relationships for the elastic moduli and viscosity of mixed lipid membranes

EG Kelley, PD Butler, R Ashkar, R Bradbury… - Proceedings of the …, 2020 - pnas.org
The elastic and viscous properties of biological membranes play a vital role in controlling
cell functions that require local reorganization of the membrane components as well as …

Membrane structure–function insights from asymmetric lipid vesicles

E London - Accounts of chemical research, 2019 - ACS Publications
Conspectus The lipid bilayer, together with embedded proteins, is the central structure in
biomembranes. While artificial lipid bilayers are useful to model natural membranes, they …

A mechanical mechanism for vitamin E acetate in e-cigarette/va**-associated lung injury

M DiPasquale, O Gbadamosi… - Chemical research in …, 2020 - ACS Publications
The outbreak of electronic-cigarette/va**-associated lung injury (EVALI) has made
thousands ill. This lung injury has been attributed to a physical interaction between toxicants …

[HTML][HTML] Model membrane systems used to study plasma membrane lipid asymmetry

HL Scott, KB Kennison, TA Enoki, M Doktorova… - Symmetry, 2021 - mdpi.com
It is well known that the lipid distribution in the bilayer leaflets of mammalian plasma
membranes (PMs) is not symmetric. Despite this, model membrane studies have largely …

A guide to your desired lipid-asymmetric vesicles

M Krompers, H Heerklotz - Membranes, 2023 - mdpi.com
Liposomes are prevalent model systems for studies on biological membranes. Recently,
increasing attention has been paid to models also representing the lipid asymmetry of …