Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

High‐throughput (HT) screening drug discovery, during which thousands or millions of
compounds are screened, remains the key methodology for identifying active chemical …

This report describes a number of substructural features which can help to identify
compounds that appear as frequent hitters (promiscuous compounds) in many biochemical …

Nanoscience includes the study of objects and systems in which at least one dimension is 1-
100 nm. The objects studied in this range of sizes are larger than atoms and small …

Spherical Nucleic Acids Page 1 Chapter 97 Exploration of the Nanomedicine-Design Space with
High-throughput Screening and Machine Learning* Gokay Yamankurt,a,b,c Eric J. Berns,d Albert …

The chemistry and topography of a surface affect biological response and are of
fundamental importance, especially when living systems encounter synthetic surfaces. Most …

This review summarizes ongoing research aimed at finding novel drugs as alternatives to
traditional antibiotics. Anti-virulence approaches, phage therapy and therapeutic antibodies …

Antibiotic resistance is a significant emerging health threat. Exacerbating this problem is the
overprescription of antibiotics as well as a lack of development of new antibacterial agents …

Most reactions can be performed in solution and on a surface, yet the challenges faced in
applying known reactions or in develo** entirely new reactions for modifying surfaces …

Covering: 2000 to 2020 Natural products and their derivatives are commercially important
medicines, agrochemicals, flavors, fragrances, and food ingredients. Industrial strategies to …