The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

Metabolomics is the discipline where endogenous and exogenous metabolites are
assessed, identified and quantified in different biological samples. Metabolites are crucial …

Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-
to-obtain in large volumes, largely free from interfering proteins or lipids and chemically …

Metabolic profiling, metabolomic and metabonomic studies mainly involve the
multicomponent analysis of biological fluids, tissue and cell extracts using NMR …

Translational motion in solution, either diffusion or fluid flow, is at the heart of chemical and
biochemical reactivity. Nuclear Magnetic Resonance (NMR) provides a powerful non …

While NMR is the most used analytical method for determining the molecular structure of
isolated chemical entities, small compounds as well as macromolecules, its capability of …

The field of metabolomics continues to witness rapid growth driven by fundamental studies,
methods development, and applications in a number of disciplines that include biomedical …

Soils, sediments, freshwaters, and marine waters contain natural organic matter (NOM), an
exceedingly complex mixture of organic compounds that collectively exhibit a nearly …

Metabolic profiling of biological samples provides important insights into multiple
physiological and pathological processes but is hindered by a lack of automated annotation …

Chemical shift variation in small-molecule 1H NMR signals of biofluids complicates
biomarker information recovery in metabonomic studies when using multivariate statistical …