Designer drugs: mechanism of action and adverse effects

D Luethi, ME Liechti - Archives of toxicology, 2020‏ - Springer
Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

[HTML][HTML] Molecular and clinical aspects of potential neurotoxicity induced by new psychoactive stimulants and psychedelics

D Rudin, ME Liechti, D Luethi - Experimental neurology, 2021‏ - Elsevier
New psychoactive stimulants and psychedelics continue to play an important role on the
illicit new psychoactive substance (NPS) market. Designer stimulants and psychedelics both …

Serotonin-releasing agents with reduced off-target effects

FP Mayer, M Niello, D Cintulova, S Sideromenos… - Molecular …, 2023‏ - nature.com
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of
depression and anxiety-related disorders, eg, social phobias and post-traumatic stress …

Vesicular monoamine transporter (VMAT) regional expression and roles in pathological conditions

M Alwindi, A Bizanti - Heliyon, 2023‏ - cell.com
Vesicular monoamine transporters (VMATs) are key regulators of neurotransmitter release
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …

[HTML][HTML] α-PPP and its derivatives are selective partial releasers at the human norepinephrine transporter: a pharmacological characterization of interactions between …

J Maier, L Rauter, D Rudin, M Niello, M Holy… - …, 2021‏ - Elsevier
While classical cathinones, such as methcathinone, have been shown to be monoamine
releasing agents at human monoamine transporters, the subgroup of α-pyrrolidinophenones …

Jump-starting the conversation about harm reduction: making sense of drug effects

M Adley, G Jones, F Measham - Drugs: Education, Prevention and …, 2023‏ - Taylor & Francis
This paper describes the history of the development of taxonomies of psychoactive drug use,
and discusses the conceptualization of three recent taxonomies: comparing their features …

Bioisosteric analogs of MDMA: Improving the pharmacological profile?

AS Alberto‐Silva, S Hemmer, HA Bock… - Journal of …, 2024‏ - Wiley Online Library
Methylenedioxymethamphetamine (MDMA,'ecstasy') is re‐emerging in clinical settings as a
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …

Interaction profiles of central nervous system active drugs at human organic cation transporters 1–3 and human plasma membrane monoamine transporter

TJF Angenoorth, S Stankovic, M Niello, M Holy… - International Journal of …, 2021‏ - mdpi.com
Many psychoactive compounds have been shown to primarily interact with high-affinity and
low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; …

Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity in vitro

M Niello, D Cintulová, P Raithmayr, M Holy… - Frontiers in …, 2021‏ - frontiersin.org
Mephedrone is a largely abused psychostimulant. It elicits the release of monoamines via
the high affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin …

DARK classics in chemical neuroscience: aminorex analogues

J Maier, FP Mayer, SD Brandt… - ACS chemical …, 2018‏ - ACS Publications
Aminorex (5-phenyl-4, 5-dihydro-1, 3-oxazol-2-amine) and 4-methylaminorex (4-methyl-5-
phenyl-4, 5-dihydro-1, 3-oxazol-2-amine) are psychostimulants that have long been listed in …