Overview of structure and function of mammalian cilia

P Satir, ST Christensen - Annu. Rev. Physiol., 2007 - annualreviews.org
Cilia are membrane-bounded, centriole-derived projections from the cell surface that contain
a microtubule cytoskeleton, the ciliary axoneme, surrounded by a ciliary membrane …

Nodal flow and the generation of left-right asymmetry

N Hirokawa, Y Tanaka, Y Okada, S Takeda - Cell, 2006 - cell.com
The establishment of left-right asymmetry in mammals is a good example of how multiple
cell biological processes coordinate in the formation of a basic body plan. The leftward …

The roles of cilia in developmental disorders and disease

BW Bisgrove, HJ Yost - 2006 - journals.biologists.com
Cilia are highly conserved organelles that have diverse motility and sensory functions.
Recent discoveries have revealed that cilia also have crucial roles in cell signaling …

Cilia: tuning in to the cell's antenna

WF Marshall, S Nonaka - Current Biology, 2006 - cell.com
Cilia are microtubule-based organelles that project like antennae from the surface of most
cells in the body. Motile cilia move fluid past cells, for example mucus in the airway. Non …

[HTML][HTML] A unified model for left–right asymmetry? Comparison and synthesis of molecular models of embryonic laterality

LN Vandenberg, M Levin - Developmental biology, 2013 - Elsevier
Understanding how and when the left–right (LR) axis is first established is a fundamental
question in developmental biology. A popular model is that the LR axis is established …

Left–right asymmetry in the vertebrate embryo: from early information to higher-level integration

Á Raya, JCI Belmonte - Nature Reviews Genetics, 2006 - nature.com
Although vertebrates seem to be essentially bilaterally symmetrical on the exterior, there are
numerous interior left–right asymmetries in the disposition and placement of internal organs …

Chapter six cilia: multifunctional organelles at the center of vertebrate left–right asymmetry

B Basu, M Brueckner - Current topics in developmental biology, 2008 - Elsevier
Cilia establish the vertebrate left–right (LR) axis and are integral to the development and
function of the kidney, liver, and brain. Left–right asymmetry is established in the ciliated …

Right, left and cilia: How asymmetry is established

RB Little, DP Norris - Seminars in Cell & Developmental Biology, 2021 - Elsevier
The initial breaking of left-right (L–R) symmetry in the embryo is controlled by a motile-cilia-
driven leftward fluid flow in the left-right organiser (LRO), resulting in L–R asymmetric gene …

[PDF][PDF] Active chiral fluids

S Fürthauer, M Strempel, SW Grill, F Jülicher - The European physical …, 2012 - Springer
Active processes in biological systems often exhibit chiral asymmetries. Examples are the
chirality of cytoskeletal filaments which interact with motor proteins, the chirality of the beat of …

Left–right determination: involvement of molecular motor KIF3, cilia, and nodal flow

N Hirokawa, Y Tanaka, Y Okada - Cold Spring Harbor …, 2009 - cshperspectives.cshlp.org
Mammalian left–right determination is a good example for how multiple cell biological
processes coordinate in the formation of a basic body plan. The leftward movement of fluid …