In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific
immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such …

Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …

Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …

Immune checkpoint inhibitors have revolutionized medical oncology, although currently only
a subset of patients has a response to such treatment. A compelling body of evidence …

Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

Cancer stemness, defined as the self-renewal and tumor-initiation potential of cancer stem
cells (CSCs), is a cancer biology property featuring activation of CSC signaling networks …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Novel neoadjuvant therapy regimens are warranted for oral squamous cell carcinoma
(OSCC). In this phase I trial (NCT04393506), 20 patients with locally advanced resectable …

Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for
the treatment of non–small cell lung cancer (NSCLC). However, only a minority of patients …