Mitochondria has an essential role in myocardial tissue homeostasis; thus deterioration in
mitochondrial function eventually leads to cardiomyocyte and endothelial cell death and …

Antineoplastic drugs can be associated with several side effects, including cardiovascular
toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX …

Success with oncologic treatment has allowed cancer patients to experience longer cancer-
free survival gains. Unfortunately, this success has been tempered by unintended and often …

Significance: Antineoplastic therapies have significantly improved the prognosis of oncology
patients. However, these treatments can bring to a higher incidence of side-effects, including …

Congestive heart failure is one of the leading causes of disability in long-term survivors of
cancer. The anthracycline antibiotic doxorubicin (DOX) is used to treat a variety of cancers …

The risk and mechanism of chemotherapy-induced cardiotoxicity (CTX) vary depending on
the type and intensity of the anticancer regimen. Myriad chemotherapeutic drugs produce …

Due to its poor capacity for regeneration, the heart is particularly sensitive to the loss of
contractile cardiomyocytes. The onslaught of damage caused by ischaemia and reperfusion …

To date, five cancer treatment modalities have been defined. The three traditional modalities
of cancer treatment are surgery, radiotherapy, and conventional chemotherapy, and the two …

Anthracycline chemotherapy has a prominent role in treating many forms of cancer.
Unfortunately, cardiotoxic side effects represent a serious limitation to their use, with …

Sodium–glucose cotransporter 2 inhibitors (SGLT2i), a new drug class initially designed and
approved for treatment of diabetes mellitus, have been shown to exert pleiotropic metabolic …