CTCF: making the right connections
R Ghirlando, G Felsenfeld - Genes & development, 2016 - genesdev.cshlp.org
The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now
well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin …
well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin …
[HTML][HTML] Chromosome condensation and decondensation during mitosis
W Antonin, H Neumann - Current opinion in cell biology, 2016 - Elsevier
Highlights•Chromatin condensation and decondensation are still ill-defined in molecular
terms.•Chromatin condensation is driven by condensins and interactions between …
terms.•Chromatin condensation is driven by condensins and interactions between …
A transient pool of nuclear F-actin at mitotic exit controls chromatin organization
Re-establishment of nuclear structure and chromatin organization after cell division is
integral for genome regulation or development and is frequently altered during cancer …
integral for genome regulation or development and is frequently altered during cancer …
DAXX adds a de novo H3. 3K9me3 deposition pathway to the histone chaperone network
A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …
until DNA deposition. They cooperate through the formation of histone co-chaperone …
The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors
H Wang, B Li, L Zuo, B Wang, Y Yan, K Tian… - Nature …, 2022 - nature.com
Abstract RNA polymerase II (Pol II) apparatuses are compartmentalized into transcriptional
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
The role of pontin and reptin in cellular physiology and cancer etiology
YQ Mao, WA Houry - Frontiers in molecular biosciences, 2017 - frontiersin.org
Pontin (RUVBL1, TIP49, TIP49a, Rvb1) and Reptin (RUVBL2, TIP48, TIP49b, Rvb2) are
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
RUVBL1–RUVBL2 AAA-ATPase: a versatile scaffold for multiple complexes and functions
MI Dauden, A López-Perrote, O Llorca - Current opinion in structural …, 2021 - Elsevier
Highlights•RUVBL1–RUVBL2 forms a scaffold in macromolecular complexes such as R2TP
and chromatin remodelers.•RUVBL1–RUVBL2 ATPase activity is regulated by client …
and chromatin remodelers.•RUVBL1–RUVBL2 ATPase activity is regulated by client …
Non-canonical roles of canonical telomere binding proteins in cancers
SC Akincilar, CHT Chan, QF Ng, K Fidan… - Cellular and Molecular …, 2021 - Springer
Reactivation of telomerase is a major hallmark observed in 90% of all cancers. Yet
paradoxically, enhanced telomerase activity does not correlate with telomere length and …
paradoxically, enhanced telomerase activity does not correlate with telomere length and …
A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex
TOPLESS are tetrameric plant corepressors of the conserved Tup1/Groucho/TLE (transducin-
like enhancer of split) family. We show that they interact through their TOPLESS domains …
like enhancer of split) family. We show that they interact through their TOPLESS domains …
Nuclear reformation at the end of mitosis
Cells have developed highly sophisticated ways to accurately pass on their genetic
information to the daughter cells. In animal cells, which undergo open mitosis, the nuclear …
information to the daughter cells. In animal cells, which undergo open mitosis, the nuclear …