Our understanding of chronic pain involves complex brain circuits that include sensory,
emotional, cognitive and interoceptive processing. The feed-forward interactions between …

The main objective of this study is to review and summarize recent findings on
electroencephalographic patterns in individuals with chronic pain. We also discuss recent …

Pain decreases the activity of many ventral tegmental area (VTA) dopamine (DA) neurons,
yet the underlying neural circuitry connecting nociception and the DA system is not …

Tinnitus and chronic pain are sensory–perceptual disorders associated with negative affect
and high impact on well-being and behavior. It is now becoming increasingly clear that …

The mesolimbic dopamine system comprises neurons in the ventral tegmental area (VTA)
and substantia nigra (SN), projecting to the ventral striatum. This system was originally …

Converging lines of evidence suggest that the pathophysiology of pain is mediated to a
substantial degree via allostatic neuroadaptations in reward-and stress-related brain …

The midbrain dopamine center comprises a key network for reward, salience, motivation,
and mood. Evidence from various clinical and preclinical settings points to the midbrain …

Suicidality is exceedingly prevalent in pain patients. Although the pathophysiology of this
link remains unclear, it may be potentially related to the partial congruence of physical and …

Decades of research advances have established a central role for endogenous opioid
systems in regulating reward processing, mood, motivation, learning and memory …

Chronic pain attenuates midbrain dopamine (DA) transmission, as evidenced by a decrease
in opioid-evoked DA release in the ventral striatum, suggesting that the occurrence of …