AI in the clinical management of GA: a novel therapeutic universe requires novel tools

GS Reiter, J Mai, S Riedl, K Birner, S Frank… - Progress in Retinal and …, 2024 - Elsevier
Regulatory approval of the first two therapeutic substances for the management of
geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a major …

[HTML][HTML] Topographic variation of the growth rate of geographic atrophy in nonexudative age-related macular degeneration: a systematic review and meta-analysis

LL Shen, M Sun, S Khetpal, HKG Nardini… - … & Visual Science, 2020 - tvst.arvojournals.org
Purpose: To determine the impact of topographic locations on the progression rate of
geographic atrophy (GA). Methods: We searched in five literature databases up to May 3 …

[HTML][HTML] Role of deep learning–quantified hyperreflective foci for the prediction of geographic atrophy progression

U Schmidt-Erfurth, H Bogunovic, C Grechenig… - American journal of …, 2020 - Elsevier
Purpose To quantitatively measure hyperreflective foci (HRF) during the progression of
geographic atrophy (GA) secondary to age-related macular degeneration (AMD) using deep …

Subretinal drusenoid deposits and photoreceptor loss detecting global and local progression of geographic atrophy by SD-OCT imaging

GS Reiter, R Told, M Schranz… - … & Visual Science, 2020 - iovs.arvojournals.org
Purpose: To investigate the impact of subretinal drusenoid deposits (SDD) and
photoreceptor integrity on global and local geographic atrophy (GA) progression. Methods …

Optical coherence tomography measurements of the retinal pigment epithelium to Bruch membrane thickness around geographic atrophy correlate with growth

Z Chu, Y Shi, X Zhou, L Wang, H Zhou… - American journal of …, 2022 - Elsevier
Purpose The retinal pigment epithelium (RPE) to Bruch membrane (BM) distance around
geographic atrophy (GA) was measured using an optical attenuation coefficient (OAC) …

Fundus autofluorescence and optical coherence tomography biomarkers associated with the progression of geographic atrophy secondary to age-related macular …

PTA Bui, GS Reiter, M Fabianska, SM Waldstein… - Eye, 2022 - nature.com
Objectives To investigate the impact of qualitatively graded and deep learning quantified
imaging biomarkers on growth of geographic atrophy (GA) secondary to age-related …

Geographic atrophy growth is strongly related to lesion perimeter: unifying effects of lesion area, number, and circularity on growth

LL Shen, M Sun, A Ahluwalia, BK Young, MM Park… - Ophthalmology …, 2021 - Elsevier
Purpose To investigate the underlying reason for the previously observed impact of baseline
lesion size, number, and circularity on geographic atrophy (GA) growth rate. Design …

Growth rate of geographic atrophy secondary to age-related macular degeneration: a meta-analysis of natural history studies and implications for designing future …

J Wang, GS Ying - Ophthalmic Research, 2021 - karger.com
Introduction: There is no effective treatment for geographic atrophy (GA). To help design
future GA treatment trials, we conducted a meta-analysis for GA growth rate and its variability …

Long-term natural history of visual acuity in eyes with choroideremia: a systematic review and meta-analysis of data from 1004 individual eyes

LL Shen, A Ahluwalia, M Sun, BK Young… - British Journal of …, 2021 - bjo.bmj.com
Background/aims Best-corrected visual acuity (BCVA) is the most common primary endpoint
in treatment trials for choroideremia (CHM) but the long-term natural history of BCVA is …

Natural history of autosomal recessive Stargardt disease in untreated eyes: a systematic review and meta-analysis of study-and individual-level data

LL Shen, M Sun, HKG Nardini, LV Del Priore - Ophthalmology, 2019 - Elsevier
Topic Systematic review and meta-analysis of the natural history of autosomal recessive
Stargardt disease (STGD1). Clinical Relevance Controversy exists regarding the …