The role of CD4 T cells in the pathogenesis of multiple sclerosis

T Chitnis - International review of neurobiology, 2007 - Elsevier
T lymphocytes play a central role in the pathogenesis of multiple sclerosis (MS)(Zhang et al.,
1992). Both CD4+ and CD8+ T cells have been demonstrated in MS lesions, with CD4+ T …

Health disparities in transplantation: focus on the complexity and challenge of renal transplantation in African Americans

CJ Young, C Kew - Medical Clinics, 2005 - medical.theclinics.com
The year 2004 marked the 50th anniversary of the first successful renal transplant performed
by Dr. Joseph Murray; subsequently, the field of renal transplantation has grown …

Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells

AE Anderson, BL Sayers, MA Haniffa… - Journal of Leucocyte …, 2008 - academic.oup.com
Promising immunotherapeutic tools for T cell-mediated pathologies are alternatively
activated dendritic cells (aaDC), which exert their effect through the regulation and …

Early steroids after pediatric liver transplantation protect against T-cell–mediated rejection: Results from the ChilSFree study

I Goldschmidt, E Chichelnitskiy, J Götz… - Liver …, 2024 - journals.lww.com
Steroid-free immunosuppression protocols gained popularity in pediatric liver
transplantation (pLT) after the introduction of IL-2–receptor blockade for induction therapy …

Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African–American renal transplant patients

DO McDaniel, WH Barber, C Nguyan, SW Rhodes… - Transplant …, 2003 - Elsevier
Cytokine gene polymorphism and expression levels were evaluated in a group of African–
American patients who had undergone renal transplantation. It was hypothesized that …

Cytokine shifts and tolerance in experimental autoimmune encephalomyelitis

T Chitnis, SJ Khoury - Immunologic research, 2003 - Springer
Cytokines play an important role in the pathogenesis of both multiple sclerosis and
experimental autoimmune encephalomyelitis (EAE). Effective treatments for both diseases …

[PDF][PDF] Early immunological monitoring after pediatric liver transplantation: cytokine immune deviation and graft acceptance in 40 recipients

J Gras, G Wieërs, JL Vaerman, DQ Truong… - Liver …, 2007 - Wiley Online Library
Cytokine deviation may be a factor contributing to graft acceptance. We analyze, in the
context of liver transplantation, circulating cytokine levels and their mRNA precursors in liver …

Analysis of cytokine gene polymorphisms in recipient's matched with living donors on acute rejection after renal transplantation

PK Manchanda, RD Mittal - Molecular and cellular biochemistry, 2008 - Springer
Despite advances in immunosuppressive therapy in last few years, allograft rejection still
remains the concern for kidney graft failure. Cytokines are key mediators in the induction …

Association of IL-6 promoter and IFN-γ gene polymorphisms with acute rejection of liver transplantation

MH Karimi, S Daneshmandi, AA Pourfathollah… - Molecular biology …, 2011 - Springer
Liver transplantation is one of the most important therapies for end-stage liver diseases and
is associated with major problems including infections and acute rejection. The outcome of …

Interleukin 6 and interleukin 17A serum levels and gene-polymorphisms in the development of early allograft rejection in living donor liver transplant recipients

SM Awad, EH El Batanony, SK Elmahdy, ET Allam… - Scientific Reports, 2024 - nature.com
The aim of this study is to evaluate the role of serum level of Interleukin 6 (IL-6) and
Interleukin 17 (IL-17) in liver transplantation outcome for living recipients, Analyze the …