Despite the success in returning people to health saving mobility and high quality of life, the
over 1 million total joint replacements implanted in the US each year are expected to …

We summarize research approaches and findings on bone healing and regeneration that
were presented at a workshop at the 60th annual meeting of the Orthopedic Research …

Introduction: Total joint replacement is one of the most common, safe, and efficacious
operations in all of surgery. However, one major long-standing and unresolved issue is the …

We aimed to investigate the association of circulatory senescence-associated secretory
phenotypes (SASPs) produced by senescent cells with chronological and menopausal age …

Objectives Aseptic loosening (AL) is the most common reason of total hip arthroplasty (THA)
failure and revision surgery. Osteolysis, caused by wear particles released from implant …

Modulation of macrophage polarization and prevention of CCL2‐induced macrophage
chemotaxis are emerging strategies to reduce wear particle induced osteolysis and aseptic …

Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement
(TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte …

Total joint replacement (TJR) is very cost-effective surgery for end-stage arthritis. One
important goal is to decrease the revision rate, mainly because TJR has been extended to …

Total joint replacement (TJR) has been widely used as a standard treatment for late‐stage
arthritis. One challenge for long‐term efficacy of TJR is the generation of ultra‐high …

Coccinia grandis (C. grandis) L is an Indian medicinal plant from the Cucurbitaceae family
whose extracts possess anti-oxidant, anti-infective, and anti-inflammatory properties. The …