Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

Mitochondria carry their own genetic information encoding for a subset of protein-coding
genes and translational machinery essential for cellular respiration and metabolism. Despite …

Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

Background Lynch syndrome is associated with an increased risk of colorectal cancer and
with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group …

Lineage tracing provides key insights into the fate of individual cells in complex organisms.
Although effective genetic labeling approaches are available in model systems, in humans …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

The recent advent of methods for high-throughput single-cell molecular profiling has
catalyzed a growing sense in the scientific community that the time is ripe to complete the …

Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for develo** cardiovascular disease because of the …

Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …

Small populations of adult stem cells are responsible for the remarkable ability of the
epithelial lining of the intestine to be efficiently renewed and repaired throughout life. The …