Early appropriate diagnostics and treatment of MDR Gram-negative infections

M Bassetti, SS Kanj, P Kiratisin… - JAC-Antimicrobial …, 2022 - academic.oup.com
The term difficult-to-treat resistance has been recently coined to identify Gram-negative
bacteria exhibiting resistance to all fluoroquinolones and all β-lactam categories, including …

Biomarkers of infection and sepsis

SM Opal, X Wittebole - Critical care clinics, 2020 - criticalcare.theclinics.com
Intensive care unit (ICU) practitioners and emergency department clinicians are in urgent
need of a major upgrade in their access to accurate and fast microbial diagnosis (Table 1) …

N95 mask decontamination using standard hospital sterilization technologies

A Kumar, SB Kasloff, A Leung, T Cutts, JE Strong… - MedRxiv, 2020 - medrxiv.org
The response to the COVID-19 epidemic is generating severe shortages of personal
protective equipment around the world. In particular, the supply of N95 respirator masks has …

Carbapenem-resistant Gram-negative bacteria (CR-GNB) in ICUs: resistance genes, therapeutics, and prevention–a comprehensive review

Q Li, X Zhou, R Yang, X Shen, G Li, C Zhang… - Frontiers in Public …, 2024 - frontiersin.org
Intensive care units (ICUs) are specialized environments dedicated to the management of
critically ill patients, who are particularly susceptible to drug-resistant bacteria. Among these …

The role of diagnostics-driven antifungal stewardship in the management of invasive fungal infections: a systematic literature review

A Chakrabarti, N Mohamed… - Open Forum …, 2022 - academic.oup.com
Antifungal stewardship (AFS) programs are key to optimizing antifungal use and improving
outcomes in patients with invasive fungal infections. Our systematic literature review …

Rapid diagnostic test value and implementation in antimicrobial stewardship across low-to-middle and high-income countries: a mixed-methods review

LSP Moore, MV Villegas, E Wenzler… - Infectious Diseases and …, 2023 - Springer
Despite technological advancements in infectious disease rapid diagnostic tests (RDTs) and
use to direct therapy at the per-patient level, RDT utilisation in antimicrobial stewardship …

Rationale for the development of a pentavalent meningococcal vaccine: a US-focused review

GS Marshall, J Fergie, J Presa, P Peyrani - Infectious Diseases and …, 2022 - Springer
While invasive meningococcal disease (IMD) is uncommon, it can result in serious sequelae
and even death. In 2018 in the United States, the incidence of IMD per 100,000 people was …

Utility and applicability of rapid diagnostic testing in antimicrobial stewardship in the Asia-Pacific region: a Delphi consensus

A Apisarnthanarak, H Bin Kim… - Clinical Infectious …, 2022 - academic.oup.com
Rapid diagnostic tests (RDTs) facilitate fast and accurate identification of infectious disease
microorganisms and are a valuable component of multimodal antimicrobial stewardship …

Opportunities to Enhance Diagnostic Testing and Antimicrobial Stewardship: A Qualitative Multinational Survey of Healthcare Professionals

T **ks, S Subramaniam, M Bassetti, AC Gales… - Infectious Diseases and …, 2024 - Springer
Introduction Antimicrobial resistance (AMR) is a global public health challenge. Global
efforts to decrease AMR through antimicrobial stewardship (AMS) initiatives include …

Identifying the need for infection-related consultations in intensive care patients using machine learning models

LR Zwerwer, CF Luz, D Soudis, N Giudice… - Scientific Reports, 2024 - nature.com
Infection-related consultations on intensive care units (ICU) have a positive impact on quality
of care and clinical outcome. However, timing of these consultations is essential and to date …