Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain
bioenergetic levels related to cellular functions. This absence of proper adaptation can be …

Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …

Although low risk localised prostate cancer has an excellent prognosis owing to effective
treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …

Lineage transitions are a central feature of prostate development, tumourigenesis and
treatment resistance. While epigenetic changes are well known to drive prostate lineage …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of
AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) …

Prostate cancer is one of the most commonly diagnosed cancers in men and is a major
cause of cancer-related deaths worldwide. Among the molecular processes that contribute …

Just like the androgen receptor (AR), the estrogen receptor α (ERα) is expressed in the
prostate and is thought to influence prostate cancer (PCa) biology. Yet the incomplete …

Although metabolic adaptations have been demonstrated to be essential for tumor cell
proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We …

Abstract Hydrogen sulfide (H2S)‐based mitochondrial bioenergetic intervention is an
attractive therapeutic modality. However, its therapeutic efficacy is limited owing to metabolic …