The major barrier to a HIV-1 cure is the persistence of latent genomes despite treatment with
antiretrovirals. To investigate host factors which promote HIV-1 latency, we conducted a …

Current antiretroviral treatment fails to cure HIV-1 infection since latent provirus resides in
long-lived cellular reservoirs, rebounding whenever therapy is discontinued. The molecular …

HIV-1 establishes a life-long reservoir of virally infected cells which cannot be eliminated by
antiretroviral therapy (ART). Here, we demonstrate a markedly altered viral reservoir profile …

HIV reservoirs are extremely stable and pose a tremendous challenge to clear HIV infection.
Here, we demonstrate that activation of ISR/ATF4 signaling reverses HIV latency, which also …

A long-lived latent reservoir of HIV-1-infected CD4 T cells persists with antiretroviral therapy
and prevents cure. We report that the emergence of latently infected primary CD4 T cells …

Low level HIV transcription during modern antiretroviral therapy (ART) in persons with HIV is
linked to residual inflammation and associated diseases, like cardiovascular disease and …

Pharmacological HIV-1 reactivation to reverse latent infection has been extensively studied.
However, HIV-1 reactivation also occurs naturally, as evidenced by occasional low-level …

Human immunodeficiency virus type 1 (HIV-1) cannot be completely eliminated because of
existence of the latent HIV-1 reservoir. However, the facts of HIV-1 latency, including its …

Les muqueuses sont des épithéliums formant une surface d'interaction avec le milieu
extérieur et protègent l'organisme des infections qui découlent de cette interaction. Ces …

Human immunodeficiency virus (HIV) infection remains a global challenge in public health,
and a deeper understanding of its immunopathogenesis is essential for the development of …