Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Mammalian mitochondrial DNA (mtDNA) is replicated and transcribed by phage-like DNA
and RNA polymerases, and our understanding of these processes has progressed …

Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Uniparental inheritance of mitochondrial DNA (mtDNA) is an evolutionary trait found in
nearly all eukaryotes. In many species, including humans, the sperm mitochondria are …

The effect of immunometabolism on age-associated diseases remains uncertain. In this
work, we show that T cells with dysfunctional mitochondria owing to mitochondrial …

The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …

Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …

Although there has been considerable debate about whether paternal mitochondrial DNA
(mtDNA) transmission may coexist with maternal transmission of mtDNA, it is generally …

Stroke is the leading cause of adult disability and mortality in most develo** and
developed countries. The current best practices for patients with acute ischemic stroke …

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells.
Owing to their ability to produce ATP through respiration, they became a driving force in …